Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR
نویسندگان
چکیده
منابع مشابه
Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is associated with familial autosomal dominant hypercholesterolemia and is a natural inhibitor of the LDL receptor (LDLr). PCSK9 is degraded by other proprotein convertases: PC5/6A and furin. Both PCSK9 and the LDLr are up-regulated by the hypocholesterolemic statins. Thus, inhibitors or repressors of PCSK9 should amplify their beneficial ef...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR.
Mutations in the proprotein convertase PCSK9 gene are associated with autosomal dominant familial hyper- or hypocholesterolemia. These phenotypes are caused by a gain or loss of function of proprotein convertase subtilisin kexin 9 (PCSK9) to elicit the degradation of the low-density lipoprotein receptor (LDLR) protein. Herein, we asked whether the subcellular localization of wild-type PCSK9 or ...
متن کاملRole of Insulin in the Regulation of Proprotein Convertase Subtilisin/Kexin Type 9.
OBJECTIVE Proprotein convertase subtilisin/kexin type 9 (PCSK9), which binds the low-density lipoprotein receptor and targets it for degradation, has emerged as an important regulator of serum cholesterol levels and cardiovascular disease risk. Although much work is currently focused on developing therapies for inhibiting PCSK9, the endogenous regulation of PCSK9, particularly by insulin, remai...
متن کاملInhibition of proprotein convertase subtilisin/kexin type 9 in the treatment of hypercholesterolemia.
Según datos de la Organización Mundial de la Salud, la enfermedad cardiovascular de origen isquémico o arterioscleroso (ECVA) es la primera causa de muerte en el mundo y especialmente en los países desarrollados. La aterosclerosis es una enfermedad arterial multifactorial, en la que el depósito en el espacio subendotelial de las lipoproteínas que transportan apolipoproteína B y colesterol, prin...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2012
ISSN: 0022-2275
DOI: 10.1194/jlr.m028563